42-50 Ormeau Road is a 0.17 acres (0.07 hectares) site which is located at the corner of Ormeau Road and Shaftesbury Avenue and has frontage to Cooke Mews. The site is currently vacant and is surrounded by metal fencing and two advertising boards.

In October 1998, Mr Andrew Bradley submitted a planning application (Z/1998/0929) proposing the construction of 4 shop/office units, 12 no. apartments and 2 no. studio apartments, car parking and access road. This application was approved in August 2000.

In October 2003, Mr Andrew Bradley submitted a planning application (Z/2003/2453/O) seeking the renewal of planning permission ref. Z/1998/0929/O for proposed construction of 4 shop/office units, 12 no. apartments and 2 no. studio apartments, car parking and access road. This application was withdrawn in November 2004.

In August 2006, Andrew Bradley Properties submitted a planning application (Z/2006/1931/F) proposing a 5 storey, 65 bedroom hotel containing restaurant, bar, conference room and car parking. This application was refused in April 2007.

In March 2007, Andrew Bradley Properties submitted a planning application (Z/2007/0758/F) proposing the development of 4 no.shop units, 17no. apartments and car parking. This application was refused in January 2009.

In March 2010, Mr Andrew Bradley submitted a planning application (Z/2010/0274/F) proposing a development containing four shop units, fourteen apartments and car parking. This application was approved in September 2012.

In August 2019, Andrew Bradley submitted a planning application (LA04/2019/1886/F) proposing the development of 13 residential apartments (one block of 11 no. apartments, one block of 2 no. apartments) with associated amenity space and site works. This application was withdrawn in February 2022.

In December 2023, Lotus Homes (UK) Ltd submitted a planning application (LA04/2024/0025/F) proposing the erection of 14 no. apartments to be delivered as social housing comprising of 11 no. 2 bed apartments and 3 no. 1 bed apartments, 2no. of which are wheelchair accessible to include amenity space, bin storage, bicycle parking provision, pedestrian and vehicular access and 2 no. disabled parking space and all associated ancillary works.